Renal inactive kallikrein as the possible origin of urinary inactive kallikrein in the rat.
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چکیده
منابع مشابه
The mechanism of urinary kallikrein excretion in the rat.
1. In male Wistar rats urinary kallikrein excretion was positively correlated with urinary flow and glomerular filtration rate (GFR). 2. Osmotic diuresis produced by a 30% (w/v) glucose solution increased urinary kallikrein, and a positive correlation between this variable and urine flow was observed. No correlation was observed with GFR. 3. The mechanism of urinary kallikrein excretion is inte...
متن کاملRenal kallikrein activity and urinary kallikrein excretion in rats with experimental renal hypertension.
1. Rats were made hypertensive by ligating the aorta between the origins of both renal arteries. Sham-operated animals served as controls. Urinary and renal kallikrein activities, as well as plasma and renal renin activities, were measured 8 and 90 days after surgery. 2. Blood pressure was 155 +/- 6 mmHg on day 8 after aortic ligature and 142 +/- 6 mmHg on day 90; in controls pressures were 107...
متن کاملRole of glandular kallikrein in the activation process of human plasma inactive renin.
Completely inactive renin was isolated from normal human plasma by DEAE-Sepharose column chromatography and Blue-Sepharose column chromatography. This inactive renin had a molecular weight of 54,000 daltons as determined by gel filtration on Ultrogel AcA 44. When the inactive renin was activated by trypsin, its molecular weight decreased to 48,000 daltons. The trypsin-activated renin differed f...
متن کاملHuman prostate-specific glandular kallikrein is expressed as an active and an inactive protein.
A polymorphism in the human prostate-specific glandular kallikrein (hKLK2) gene was described by direct sequencing (by PCR) of genomic DNAs isolated from prostatic cancer tissue, benign prostatic hyperplasia tissue, and blood leukocyte specimens. Results showed two forms of human prostate-specific glandular kallikrein protein (hK2), a consequence of a change from C to T at base 792 in the hK2 c...
متن کاملUrinary Kallikrein Excretion
A preliminary report of the data was presented at the Southem Section Meeting of The American Federation for Clinical Research in New Orleans, La. in January 1976. Received for publication 1 May 1978 and in revised form 5 October 1979. tion vs. race and age-matched normal subjects. Stimulation of urinary kallikrein excretion by Florinef was equal in black and white normal subjects vs. hypertens...
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ژورنال
عنوان ژورنال: Journal of Pharmacobio-Dynamics
سال: 1985
ISSN: 0386-846X,1881-1353
DOI: 10.1248/bpb1978.8.175